Fig. 3

Functional Analysis of PR Cells. A, C Representative enriched GO terms (Biological Process) for upregulated (A) and downregulated (C) genes (|log₂FC|≥ 0.5 and adjusted P < 0.05) in Surv⁻ epithelial cells, respectively. B, D KEGG pathways associated with upregulated (B) and downregulated (D) genes (|log₂FC|≥ 0.5 and adjusted P < 0.05) in Surv⁻ epithelial cells, respectively. E, G Representative enriched GO terms (Biological Process) for upregulated (E) and downregulated (G) genes (|log₂FC|≥ 0.5 and adjusted P < 0.05) in Surv⁻ T cells, respectively. F, H KEGG pathways associated with upregulated (F) and downregulated (H) genes (|log₂FC|≥ 0.5 and adjusted P < 0.05) in Surv⁻ T cells, respectively. I–K Normalized expression of marker genes related to myofibroblasts (I), complement-related genes (J), and inflammatory cancer-associated fibroblasts (iCAFs) (K) across PR fibroblast subsets. L UMAP plot of T cells re-clustered from Fig. 1B, with each color-coded region representing a distinct cell type. M, N Expression of effector (M) and exhaustion markers (N) for PR T cells on the UMAP map. Color key from gray to pink indicates relative expression levels from low to high. PR cells, prognostic-related cells; GO, Gene ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; iCAFs, inflammatory cancer-associated fibroblasts