Fig. 1

Changes in DNA methylation among active SLE patients were associated with remission status. A Differential methylation change between baseline flare and follow-up visits by remission status, with Model 1 covariates (in red, Bonferroni p < 0.05 and coefficient absolute value ≥ 0.1). Black line indicates Bonferroni significance. B Among CpGs with Bonferroni p < 0.05 and coefficient absolute value ≥ 0.1, average methylation change from baseline flare to follow-up visit for remitters (x-axis) and non-remitters (y-axis). Coefficients shown were from Model 1. Quadrants one (red) and three (blue) represent methylation changes in the same direction of effect (hypo- or hyper-methylation) for remitters and non-remitters. Quadrants 2 (green) and four (purple) represent opposite direction of methylation change between groups