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Table 3 Five most significant differentially methylated regions between pleural mesothelioma and healthy pleura

From: Genome-wide DNA methylation analysis reveals a unique methylation pattern for pleural mesothelioma compared to healthy pleura and other lung diseases

Chrom

Start

Stop

Width

Number of CpGs

HMFDR

Maxdiff

Meandiff

Overlapping genes

chr6

30,038,254

30,039,466

1213

20

7,61E-34

0,474,573,918

0,229,528,006

RNF39

chr2

220,298,547

220,300,568

2022

13

2,79E-30

0,378,931,486

0,140,166,887

SPEG

chr22

32,057,065

32,058,810

1746

8

1,17E-27

 − 0,335,338,607

 − 0,173,441,195

PISD

chr17

75,281,339

75,284,193

2855

13

5,72E-26

 − 0,396,400,033

 − 0,230,612,988

SEPT9

chr8

128,806,271

128,808,554

2284

13

7,98E-26

 − 0,486,066,199

 − 0,181,561,728

PVT1

  1. HMFDR: harmonic mean of the individual CpG P-values (FDR-corrected)