A meta-analysis of epigenome-wide association studies of ultra-processed food consumption with DNA methylation in European children

Table 4 Protein complex gene sets annotated to CpGs associated with UPF with a p value < 10^–4

TERM^a	N^b	DE^c	P	FDR
Regulation of apoptosis by parathyroid hormone-related protein	2	21	< 0.001	0.002
LKB1 signalling events (PID)	2	43	0.001	0.005
Thyroid hormones production and their peripheral downstream signalling effects	2	74	0.002	0.010
Fragile X syndrome	2	119	0.002	0.010
Thyroid hormone signalling pathway	2	121	0.004	0.015
Transcriptional deregulation in cancer	2	192	0.010	0.031
MicroRNAs in cancer--Homo sapiens (human) (KEGG)	2	310	0.025	0.061
PI3K-Akt signalling pathway	2	340	0.030	0.061
PI3K-Akt signalling pathway	2	354	0.032	0.061
Transcriptional Regulation by TP53	2	361	0.034	0.061

^aTerm from complex gene sets from ConsensusPathDB[66]
^bNumber of genes of UPF-related CpGs overlapping with the genes annotated to the ConsensusPathDB term
^cTotal number of genes in the ConsensusPathDB term

ISSN: 1868-7083