Table 3 Genomic context and biological exposures and traits previously associated with suggestive CpGs
CpG ID (UPF association) | Chromosome | Position | Relation to island | Gene region | Nearest gene | eQTM a | EWAS catalog (tissue exposure direction) b | Ewas atlas (biological traits) c |
|---|---|---|---|---|---|---|---|---|
cg14665028 ( +) | 2 | 220,024,924 | Island | 5'UTR | NHEJ1 | 0 | Buccal cells tissue versus blood [95] | No results |
cg18968409 ( +) | 2 | 34,633,637 | Open Sea | 0 | Whole blood: age (−) [74] | Adults: hepatocellular carcinoma HCC ( +) [78] | ||
cg00339913 (−) | 8 | 22,085,227 | Open Sea | Body | PHYHIP | 0 | Whole blood: age (−) [74] | Papillary thyroid carcinoma (−) [77] |
cg03041696 (−) | 14 | 21,094,001 | S Shore | 0 | Whole blood: age (−) [74] | Mother–newborns: alcohol consumption ( +) [96] | ||
cg24730307 ( +) | 22 | 24,405,009 | N Shelf | 0 | Buccal cells tissue vs blood [95] | No results | ||
cg09709951 ( +) | 12 | 54,017,699 | N Shelf | 5'UTR | ATF7 | 2 (ATF) | Whole blood: age ( +)[74] sex ( +)[74] Adults: juice consumption (−) [75] | SETD1B-neurodevelopment-related syndrome ( +) [73] |
cg03999434 (−) | 12 | 1,639,034 | Island | 0 | Whole blood: age ( +)[74] sex (−) [74] Liver: adult liver versus foetus (−) [76] | Adults: asthma (−) [97] air pollution (−) [98] Children: age (−) [99] |