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Table 1 Characteristics of mothers and children in all participating cohorts

From: A meta-analysis of epigenome-wide association studies of ultra-processed food consumption with DNA methylation in European children

N

Cohorts (N = 3152)

HELIX

G21

ALSPAC

GenR

1138

732

892

390

Share of UPF in the diet in %a (mean (SD))

24 (9)

34 (13)

61 (12)

36 (11)

Child sex: male (N (%))

627 (55.1)

392 (53.6)

442 (49.6)

200 (51.3)

Child age (mean (SD)) (years)

7.81 (1.55)

9.72 (0.23)

7.45 (1.68)

9.76 (0.26)

White European Ancestry (N (%))

1014 (89.1)

711 (97.1)

890 (99.8)

390 (100)

Child sedentary behaviour (min/day)b

240 (131)

492 (67)

 

124 (71)

Child sedentary behaviour (N (%))

    

 Screen time 1 h/day

  

246 (27.6)

 

 1-2 h/day

  

581 (65.1)

 

 3 h/day or more

  

65 (7.3)

 

Child BMI (mean (SD)) (kg/m2)

16.8 (2.6)

18.6 (3.2)

16.2 (2.0)

17.1 (2.0)

Total vegetables intake (grams/week)c

  

197 (24)

98 (59)

Total vegetables intake (N (%))

    

 < 6 (servings/week)

573 (50.4)

188 (25.7)

  

 6.0–8.5 (servings/week)

216 (19.0)

346 (47.3)

  

 > 8.5 (servings/week)

349 (30.7)

119 (16.3)

  

 NA

 

79 (10.8)

  

Total fruit intake (grams/week) d

  

551 (513)

126 (68)

Total fruit intake(N (%))

    

 < 7 (servings/week)

372 (32.7)

387 (52.9)

  

 7–14.1 (servings/week)

384 (33.7)

207 (28.3)

  

 > 14.1 (servings/week)

382 (33.6)

59 (8.1)

  

NA

 

79 (10.8)

  

Maternal education (N (%)) e

    

 Low

170 (14.9)

304 (41.5)

251 (28.1)

29 (7.4)

 Middle

383 (33.7)

209 (28.6)

431 (48.3)

197 (50.5)

 High

585 (51.4)

219 (29.9)

210 (23.5)

164 (42.1)

Maternal pre-pregnancy BMI (mean (SD)) (kg/m2)

25.0 (4.9)

24.5 (4.5)

22.9 (3.6)

24.6 (4.1)

Maternal age f (mean (SD)) (years)

30.7 (4.9)

29.6 (5.2)

29.7 (4.3)

42.4 (3.9)

Maternal active smoking during pregnancy (N (%))

168 (14.8)

153 (20.9)

161 (18.0)

47 (12.1)

  1. aShare of UPF in the total diet was expressed as percentage of total energy derived from UPF in ALSPAC and G21, and percentage of servings to the total servings of food and drinks ingested in HELIX and GenR
  2. bSedentary behaviour in HELIX is defined as minutes/day spent watching a screen, in G21 as minutes/day without doing sport, GenR as minutes/day viewing television and computer game use
  3. c,dTotal vegetables and fruit intake in ALSPAC and in GenR is a continuous variable expressed in grams/week
  4. eMaternal education in G21 is categorized in years of schooling (< 9 years, 9–12 years and > 12 years). The categories for maternal education in ALSPAC are: O level/vocational/CSE/no education qualifications, medium (A level), high (degree). The categories for GenR are: low (no/primary education), intermediate (secondary school, vocational training), and high (bachelor’s degree, university)
  5. fMaternal age at birth for HELIX, G21, and ALSPAC and at child assessment for GenR
  6. All continuous variables were expressed as mean ± SD while categorical variables are expressed as numbers, n (%)