Table 2 Associations between road traffic noise (linear, per 10-dB increase in 5-y mean exposure at baseline) and DNA methylation
From: Road traffic noise and breast cancer: DNA methylation in four core circadian genes
Gene/CpG | Road traffic noise and methylation | ||
|---|---|---|---|
Alla | Non-casesa n = 292 | Casesa n = 318 | |
Beta (SE), p-value | Beta (SE), p-value | Beta (SE), p-value | |
CRY1 CpG1 | −0.13 (0.07), 0.06 | −0.05 (0.10), 0.59 | −0.22 (0.10), 0.03 |
CRY1 CpG2 | −0.17 (0.07), 0.01 | −0.05 (0.09), 0.59 | −0.30 (0.10), 0.002 |
CRY1 CpG3 | −0.05 (0.07), 0.45 | 0.06 (0.10), 0.55 | −0.17 (0.10), 0.11 |
CRY1 CpG4 | −0.08 (0.07), 0.25 | 0.02 (0.10), 0.84 | −0.21 (0.10), 0.04 |
CRY1 CpG5 | −0.03 (0.08), 0.71 | 0.01 (0.11), 0.95 | −0.05 (0.11), 0.68 |
CRY1 CpG6 | −0.09 (0.05), 0.08 | 0.01 (0.07), 0.95 | −0.19 (0.07), 0.01 |
CRY1 CpG7 | −0.02 (0.06), 0.70 | 0.07 (0.09), 0.43 | −0.14 (0.10), 0.16 |
CRY1 CpG8 | −0.07 (0.07), 0.27 | 0.02 (0.09), 0.83 | −0.16 (0.10), 0.09 |
CRY1 CpG9 | −0.12 (0.07), 0.12 | −0.03 (0.10), 0.74 | −0.21 (0.11), 0.06 |
CRY1 CpG10 | −0.10 (0.08), 0.24 | −0.01 (0.11), 0.93 | −0.20 (0.12), 0.10 |
CRY1 CpG11 | −0.04 (0.06), 0.53 | 0.07 (0.08), 0.36 | −0.15 (0.09), 0.09 |
CRY1 CpG12 | −0.14 (0.07), 0.05 | −0.11 (0.10), 0.27 | −0.20 (0.10), 0.05 |
BMAL1 CpG1 | −0.02 (0.06), 0.68 | 0.03 (0.08), 0.68 | −0.09 (0.09), 0.32 |
BMAL1 CpG2 | −0.13 (0.05), 0.01 | −0.13 (0.07), 0.07 | −0.12 (0.07), 0.09 |
BMAL1 CpG3 | −0.08 (0.06), 0.18 | −0.13 (0.08), 0.09 | −0.04 (0.09), 0.61 |
BMAL1 CpG4 | 0.01 (0.05), 0.95 | −0.01 (0.07), 0.97 | 0.02 (0.07), 0.83 |
BMAL1 CpG5 | −0.04 (0.05), 0.38 | −0.04 (0.07), 0.53 | −0.02 (0.07), 0.73 |
BMAL1 CpG6 | −0.12 (0.05), 0.01 | −0.15 (0.08), 0.07 | −0.11 (0.07), 0.12 |
BMAL1 CpG7 | −0.13 (0.06), 0.04 | −0.20 (0.09), 0.02 | −0.04 (0.08), 0.61 |
CLOCK CpG1 | −0.04 (0.06), 0.48 | −0.11 (0.08), 0.15 | 0.03 (0.08), 0.70 |
CLOCK CpG2 | −0.02 (0.06), 0.68 | 0.04 (0.09), 0.62 | −0.12 (0.08), 0.17 |
CLOCK CpG3 | −0.04 (0.06), 0.51 | −0.08 (0.09), 0.32 | 0.02 (0.08), 0.82 |
CLOCK CpG4 | −0.03 (0.06); 0.57 | −0.02 (0.09), 0.85 | −0.08 (0.09), 0.35 |
CLOCK CpG5 | −0.07 (0.06), 0.18 | −0.04 (0.08), 0.59 | −0.09 (0.08), 0.25 |
PER1 CpG1 | −0.03 (0.06), 0.61 | −0.01 (0.08), 0.97 | −0.07 (0.08), 0.38 |
PER1 CpG2 | −0.02 (0.06), 0.78 | 0.02 (0.08), 0.79 | −0.04 (0.09), 0.63 |
PER1 CpG3 | 0.02 (0.06), 0.68 | 0.11 (0.08), 0.14 | −0.08 (0.09), 0.39 |
PER1 CpG4 | −0.05 (0.07), 0.46 | 0.04 (0.09), 0.66 | −0.16 (0.10), 0.10 |
PER1 CpG5 | −0.01 (0.02), 0.52 | −0.01 (0.03), 0.68 | −0.01 (0.03), 0.77 |