From: Road traffic noise and breast cancer: DNA methylation in four core circadian genes
Baseline characteristics | Total (N = 610) | Non-cases (n = 292) | All breast cancer cases (n = 318) | ER +  breast cancer (n = 275) | ER– breast cancer (n = 43) |
---|---|---|---|---|---|
Age, years (mean ± SD) | 56.3 ± 7.3 | 56.6 ± 7.3 | 55.9 ± 7.1 | 55.8 ± 7.1 | 56.9 ± 7.1 |
5-year mean road traffic noise at baseline, median (5–95%) | 54.2 (40.4–67.4) | 54.7 (41.0–67.5) | 54.0 (40.0–66.9) | 54.2 (40.3–66.9) | 54.1 (38.6–68.1) |
Parity, % | Â | Â | Â | Â | Â |
 Nulliparous | 13.9 | 12.7 | 15.1 | 14.9 | 16.3 |
 Parous | 86.1 | 87.3 | 84.9 | 85.1 | 83.7 |
Age at first birth | 24.8 ± 4.6 | 24.6 ± 4.4 | 25.0 ± 4.7 | 24.9 ± 4.5 | 25.6 ± 6.2 |
Menopause, % | Â | Â | Â | Â | Â |
 Still menstruating | 30.2 | 28.8 | 31.5 | 32.4 | 25.6 |
 Menopausal | 67.2 | 68.8 | 65.7 | 65.1 | 69.8 |
 Unknown | 2.6 | 2.4 | 2.8 | 2.5 | 4.7 |
Educational level, % | Â | Â | Â | Â | Â |
 Low | 67.2 | 69.2 | 65.4 | 65.1 | 67.4 |
 Medium | 15.9 | 16.4 | 15.4 | 15.3 | 16.3 |
 High | 16.9 | 14.4 | 19.2 | 19.6 | 16.3 |
Civil status, % | Â | Â | Â | Â | Â |
 Single/divorced/ widow(er) | 37.0 | 40.7 | 33.6 | 32.4 | 41.9 |
 Married/cohabiting | 63.0 | 59.3 | 66.4 | 67.6 | 58.1 |
Occupational status (%) | Â | Â | Â | Â | Â |
 Gainfully employed | 68.9 | 66.8 | 70.8 | 71.3 | 67.4 |
 Unemployed | 7.5 | 8.2 | 6.9 | 6.9 | 7.0 |
 Retired | 23.6 | 25.0 | 22.3 | 21.8 | 25.6 |
Physical activity, % | Â | Â | Â | Â | Â |
 Low | 50.8 | 48.3 | 53.1 | 52.0 | 65.1 |
 Medium | 21.9 | 24.0 | 20.1 | 19.6 | 23.3 |
 High | 26.3 | 26.7 | 26.8 | 28.4 | 11.6 |
Inconvenient working hours/shiftwork, % | Â | Â | Â | Â | Â |
 Yes | 23.8 | 26.7 | 21.1 | 22.2 | 14.3 |
 No | 75.1 | 71.9 | 78.0 | 77.8 | 85.7 |
BMI (kg/m2), mean ± SD | 25.3 ± 3.9 | 25.1 ± 3.9 | 25.4 ± 4.0 | 25.5 ± 4.0 | 24.7 ± 3.8 |
Waist circumference (cm), mean ± SD | 77.4 ± 10.2 | 77.1 ± 10.0 | 77.6 ± 10.4 | 77.9 ± 10.6 | 76.3 ± 8.8 |
Smoking, % | Â | Â | Â | Â | Â |
 Current | 25.1 | 31.2 | 19.5 | 20.7 | 11.6 |
 Former | 29.5 | 23.6 | 34.9 | 34.9 | 34.9 |
 Never | 45.4 | 45.2 | 45.6 | 44.4 | 53.5 |
Smoking intensity (g/day)b, mean ± SD | 12.1 ± 6.7 | 11.4 ± 5.9 | 13.1 ± 7.6 | 12.9 ± 7.5 | 14.8 ± 9.6 |
Alcohol intake (g/day)b, mean ± SD | 10.7 ± 9.6 | 10.8 ± 9.6 | 10.6 ± 9.7 | 10.8 ± 9.9 | 9.1 ± 8.2 |
PM2.5 (µg/m3)c, mean ± SD | 9.8 ± 2.4 | 9.8 ± 2.4 | 9.7 ± 2.4 | 9.8 ± 2.3 | 9.5 ± 3.3 |
NOx (µg/m3)c, mean ± SD | 36.2 ± 13.6 | 36.6 ± 13.3 | 35.8 ± 13.9 | 35.4 ± 13.1 | 38.8 ± 18.2 |