Table 2 ncRNAs regulated by histone modification in DSCs
From: Epigenetic modifications involving ncRNAs in digestive system cancers: focus on histone modification
Hitone modification | Histone target | Enzyme | ncRNAs | Expression | Molecular axis | Type of cancers | PMID |
|---|---|---|---|---|---|---|---|
Acetylated | – | p300/HDAC1 | lncRNA-Ip53 | Upregulation | p53/lnc-Ip53/p300, HDAC1/p53 | Hepatocellular carcinoma | 33173727 |
Acetylated | H3K27ac | CBP | lncRNA EIF3J‐AS1 | Upregulation | lncRNA EIF3J-AS1/miR‐3163/YAP1 | Colorectal carcinoma | 31709617 |
Acetylated | H3K14ac | HDAC3 | lncRNA-LOC101928316 | Downregulation | HDAC3/LOC101928316/PI3K/Akt/mTOR | Gastric carcinoma | 34427099 |
Acetylated | H3ac | HDAC3 | lncRNA-LET | Downregulation | HDAC3/lncRNA-LET/miR-548k | Gastric carcinoma | 34936297 |
Acetylated | – | HDAC1 | lncRNA ZNFTR | Downregulation | HIF-1α/HDAC1/lncRNA ZNFTR/ATF3/ZNF24/VEGFA | Pancreatic carcinoma | 34480024 |
Acetylated | H4ac | HAT1 | lncRNA PVT1 | Upregulation | HAT1/BRD4/lncRNA PVT1 | Pancreatic carcinoma | 34564701 |
Acetylated | H3K27ac | CBP | lncRNA LOC146880 | Upregulation | lncRNA LOC146880/miR-328-5p/FSCN1/MAPK | Esophageal carcinoma | 34016787 |
Acetylated | H3K27ac | CBP | lncRNA PLAC2 | Upregulation | lncRNA PLAC2/Wnt/β-catenin | Oral squamous cell carcinoma | 30720068 |
Acetylated | H3K27ac | CBP | lncRNA FOXC2-AS1 | Upregulation | lncRNA FOXC2-AS1/miR-6868-5p/E2F3 | Tongue squamous cell carcinoma | 34358374 |
Acetylated | – | HDAC2 | lncRNA MIR22HG | Downregulation | HDAC2/lncRNA MIR22HG/miR-22-5p | Hepatocellular carcinoma | 33718133 |
Acetylated | H3/H4ac | HDAC3 | lncRNA ANCR | Upregulation | HDAC3/LncRNA ANCR/miR-140-3p/HNRNPA1 | Hepatocellular carcinoma | 31868085 |
Acetylated | H3/H4ac | HDAC1 | miR-34a | Downregulation | HDAC1/miR-34a/TGF-β/Smad4/CTGF, IL-11 | Hepatocellular carcinoma | 31349837 |
Acetylated | H3K9ac | SIRT1 | miR-1185-1 | Downregulation | SIRT1/miR-1185-1/CD24 | Colorectal carcinoma | 33046442 |
Acetylated/Methylated | H3K27ac/H3K4me3 | EP300/WDR5 | circSOD2 | Upregulation | circSOD2/miR-502-5p/DNMT3a/JAK2/STAT3/EP300, WDR5 loop | Hepatocellular carcinoma | 33234142 |
Methylated | H3K9me1 | ESET | lncRNA GMDS-AS1 | Downregulation | ESET/lncRNA GMDS-AS1/PSMB1 | Hepatocellular carcinoma | 36737533 |
Methylated | H3K9me3/H3K36me3 | JMJD2C | lncRNA MALAT1 | Upregulation | JMJD2C/lncRNA MALAT1/β-Catenin | Colorectal carcinoma | 31665047 |
Methylated | H3K27me3 | EZH2 | miR-381 | Downregulation | EZH2/miR-381/SETDB1/PI3K/AKT | Hepatocellular carcinoma | 35184652 |
Methylated | H3K27me3 | EZH2 | miR-1224 | Downregulation | CREB/EZH2/miR-1224/YAP | Hepatocellular carcinoma | 33614242 |
Methylated | H3K27me3 | EZH2 | miR-124 | Downregulation | EZH2/miR-124 | Esophageal carcinoma | 31197517 |
Methylated | H3K79me2 | DOT1L | miR-448 | Downregulation | CDK11B/SPDEF/miR-448/DOT1L | Hepatocellular carcinoma | 33328586 |