Fig. 2

Contacts of the MLH1 promoter. Profiles of MLH1 promoter contacts in control (CTRL, green) and epimutant (CME, purple) cell lines for the non-MAA and the MAA. The viewpoint is indicated by the black triangle. Protein coding gene annotation and transcriptional direction are shown at the top. Below, the UMI-4C contacts normalised trends and its corresponding windows, with fill representing the log₁₀ odds ratio of the contact differences in epimutant versus control cells. Asterisks on top of the windows indicate significant differences in the 3D contacts (FDR adjusted p-value < 0.05). The domainogram at the bottom shows the mean contact intensity log₂ fold changes with increasing resolution between the two groups. Colour scale is the same in all graphs: green and purple indicate lost and gained contacts, respectively, in epimutant cells compared to controls