Fig. 1

Results on the survival modeling for individual CpG sites associated with breast cancer; A Volcano plot of Model 1 (MZ + DZ) with CpG sites significantly associated with breast cancer marked in red; B Comparison between Model 1 (MZ + DZ) and Model 2 (MZ) with significant CpG sites from Model 1 validated in Model 2 marked in red; C Comparison between Model 2 (MZ) and Model 3 (DZ) with a regression line in blue (regression coefficient = 1.31, p = 0.001); D Comparison between Model 1 (MZ + DZ, Finnish data) and Model 2R (MZ + DZ, Danish data) with replicated CpG site in red