Fig. 4

Prioritized 2378 discordant CpG-gene pairs marking discordant set points of gene expression between hCiC and hPACs. A Circos plot showing the distribution of N = 2378 differential CpG-gene pairs across the genome. Labeled are N = 15 CpG-gene pairs with highest correlation between methylation and expression levels. The outer circle displays the gene expression. Blue shows downregulated genes, while red shows upregulated genes. The inside circle represents DNA methylation from CpGs that mapped in direct vicinity of DEGs, where blue is hypomethylated and red is hypermethylated. B Visualization of notable significant pathways enriched among 2378 CpG-gene pairs lower and higher expressed in hCiCs relative to hPACs showing the links between genes and biological processes by using GO and KEGG networks. C Notable significant pathway enriched for CpG-gene pairs that were higher expressed in hCiCs relative to hPACs showing the links between genes and biological processes by using GO and KEGG networks. Size of the dots represents number of genes linked to each term. The color of the dots represents the fold change of the differentially expressed gene. P adjusted method = FDR depicted in the histograms