DNA methylation at AHRR as a master predictor of smoke exposure and a biomarker for sleep and exercise

Clinical Epigenetics

Table 4 List of lifestyle behaviors significantly associated with DNA methylation at AHRR cg05575921 in a group of N = 737 individuals

Lifestyle/demographic factor	AHRR cg05575921 association test
Lifestyle/demographic factor	B	Std. error	Std. B	R²	p
Age	− 0.001	0.0002	− 0.155	0.020	1.89E–05
Sex male (ref. female)	− 0.031	0.006	− 0.174	0.026	1.67E–06
Smoking
Current smoker (ref. never smoker)	− 0.104	0.007	− 0.516	0.252	4.71E–41
Current smoker (ref. former smoker)	− 0.092	0.011	− 0.424	0.100	6.24E–15
Former smoker (ref. never smoker)	− 0.028	0.005	− 0.221	0.065	6.65E–08
Lifestyle risk factors
Sleep hours ≥ 8 h (ref. < 8 h.)	0.021	0.010	0.045	0.012	0.027
Physical activity (PA) (ref. no PA)	0.009	0.004	0.040	0.027	0.028
PA freq. (ref. none)
Once a month	− 0.001	0.008	− 0.003	0.007	0.930
Once a week	0.011	0.005	0.053	0.038	0.037
Every day	0.012	0.005	0.058	0.034	0.028

Table shows the results of univariate linear regression analysis with DNA methylation at AHRR as dependent variable and each lifestyle factor introduced in separate models as independent variable, adjusted for age, sex, smoking status and blood cell count
Reference categories are provided for each lifestyle/demographic factors tested

ISSN: 1868-7083