DNA methylation at AHRR as a master predictor of smoke exposure and a biomarker for sleep and exercise

Clinical Epigenetics

Table 3 Predictive performance for binomial and multinomial models for smoking status

Model type	Smoking category	Training set	Test set
Model type	Smoking category	AUC	Sensitivity	Specificity	AUC	Sensitivity	Specificity
AHRR cg05575921	Smoker vs. never smoker	0.75	0.56	0.82	0.76	0.60	0.82
Binomial 4-CpG	Smoker vs. never smoker	0.80	0.64	0.82	0.80	0.66	0.82
Multinomial 4-CpG	Cat. 1 Never smoker	0.80	0.84	0.57	0.80	0.84	0.66
	Cat. 2 Light smoker	0.68	0.39	0.82	0.69	0.44	0.80
	Cat. 3 Heavy smoker	0.89	0.56	0.97	0.88	0.52	0.97

ISSN: 1868-7083