Fig. 3
From: Comparison of cell type and disease subset chromatin modifications in SLE
Pathway analysis of lupus nephritis versus general SLE. Differentially bound ChIP-seq peaks up and down in lupus nephritis compared to general SLE were used for Fast Gene Enrichment Analysis (fgsea) analysis of Hallmark pathways. The cutoff for genes analyzed was FDR < 0.1 and genes were ranked by log2 fold change in fgsea. Only monocyte data is displayed. No significant differences were observed for T cells and B cells. Pathways enriched in lupus nephritis have a positive normalized enrichment score, and pathways with decreased enrichment in lupus nephritis have a negative normalized enrichment score. The color scale indicates the significance (p-value < 0.05) and the size of the circle reflects the absolute value of the normalized enrichment score. Pathways with an adjusted p-value > 0.05 are colored in gray