Fig. 2
From: Comparison of cell type and disease subset chromatin modifications in SLE
Pathway analysis of cutaneous versus general SLE. Differentially bound ChIP-seq peaks up and down in cutaneous compared to general SLE were used for Fast Gene Enrichment Analysis (fgsea) analysis of Hallmark pathways. The cutoff for genes analyzed was FDR < 0.1 and genes were ranked by log2 fold change in fgsea. Only monocyte data is displayed. B cells had no significant differences and T cell had a single pathway altered in SLE (TNF). Pathways enriched in cutaneous lupus have a positive normalized enrichment score, and pathways with decreased enrichment in cutaneous lupus have a negative normalized enrichment score. The color scale indicates the significance (p-value < 0.05) and the size of the circle reflects the absolute value of the normalized enrichment score. Pathways with an adjusted p-value > 0.05 are colored in gray