Fig. 1
From: Comparison of cell type and disease subset chromatin modifications in SLE
Pathway analysis of SLE versus control. Differentially bound ChIP-seq peaks up and down in SLE compared to control were used for Fast Gene Enrichment Analysis (fgsea) analysis of Hallmark pathways. The cutoff for genes analyzed was FDR < 0.1 and the genes were ranked by log2 fold change in fgsea. The analyses are divided by antibody type and cell type. Pathways enriched in SLE have a positive normalized enrichment score, and pathways with decreased enrichment in SLE have a negative normalized enrichment score. The color scale indicates the significance (p-value < 0.05) and the size of the circle reflects the absolute value of the normalized enrichment score. Pathways with an adjusted p-value > 0.05 are colored in gray