Table 5 EUR MR analysis result: the CVH score on EAA
From: Causal effects of cardiovascular health on five epigenetic clocks
| Â | No. of SNPs | F | IVW | Weighted Median | MR-Egger | MR-PRESSO | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
β (SE) | p-value | β (SE) | p-value | β (SE) | p-value | No. of outliers | β (SE) | p-value | |||
HannumEAA (years) | |||||||||||
CVH score | 11 | 33 | − 0.095 (0.180) | 5.99E-01 | − 0.352 (0.243) | 1.48E-01 | − 0.040 (0.630) | 9.51E-01 | 0 | − 0.095 (0.176) | 6.02E-01 |
CVH score (without CVD) | 11 | 30 | − 0.098 (0.190) | 6.04E-01 | − 0.325 (0.245) | 2.00E-01 | − 0.032 (0.589) | 9.58E-01 | 0 | − 0.098 (0.186) | 6.08E-01 |
IEAA (years) | |||||||||||
CVH score | 11 | 33 | − 0.389 (0.186) | 3.60E-02 | − 0.357 (0.239) | 1.36E-01 | 0.265 (0.628) | 6.83E-01 | 0 | − 0.389 (0.116) | 7.41E-03 |
CVH score (without CVD) | 11 | 30 | − 0.404 (0.196) | 3.89E-02 | − 0.377 (0.251) | 1.33E-01 | 0.224 (0.587) | 7.11E-01 | 0 | − 0.404 (0.125) | 8.85E-03 |
PhenoEAA (years) | |||||||||||
CVH score | 11 | 33 | − 0.450 (0.248) | 7.00E-02 | − 0.376 (0.314) | 2.31E-01 | 0.355 (0.869) | 6.92E-01 | 0 | − 0.450 (0.248) | 1.00E-01 |
CVH score (without CVD) | 11 | 30 | − 0.461 (0.265) | 8.18E-02 | − 0.395 (0.341) | 2.47E-01 | 0.371 (0.811) | 6.58E-01 | 0 | − 0.461 (0.265) | 1.21E-01 |
GrimEAA (years) | |||||||||||
CVH score | 11 | 33 | − 0.526 (0.244) | 3.10E-02 | − 0.466 (0.273) | 8.70E-02 | − 0.698 (0.868) | 4.42E-01 | 0 | − 0.526 (0.244) | 5.64E-02 |
CVH score (without CVD) | 11 | 30 | − 0.551 (0.258) | 3.23E-02 | − 0.592 (0.264) | 2.47E-02 | − 0.610 (0.816) | 4.73E-01 | 0 | − 0.551 (0.258) | 5.80E-02 |
DNAm PAI-1 (pg/ml) | |||||||||||
CVH score | 11 | 33 | − 0.586 (0.507) | 2.48E-01 | − 0.874 (0.640) | 1.76E-01 | − 2.110 (2.335) | 3.90E-01 | 0 | − 0.586 (0.507) | 2.75E-01 |
CVH score (without CVD) | 11 | 30 | − 0.618 (0.541) | 2.53E-01 | − 0.727 (0.688) | 2.91E-01 | − 1.718 (2.218) | 4.59E-01 | 0 | − 0.618 (0.541) | 2.80E-01 |