Fig. 1

Variability associated with genetic factors (sex and genetic variants) in the TACT study. a Sex chromosome-associated probes demonstrate high variability both within population at visit 1 (SDβ, x-axis) and over time (∆β, y-axis). b Example of β value and intensity of an X-chromosome-associated probe in males and females. c Example of β value and intensity of a Y-chromosome-associated probe in males and females. d Two types of type II probes SNPs and their impact on signal intensity: SNPs in position 0 (SNP-II-0) result in false green or red signals, while SNPs in position 1 (SNP-II-1) result in a loss of signal (for type I probes see Supplementary Fig. S2a). e SNPs in position 0 and 1 both demonstrate high variability in the population at visit 1 (SDβ), but SNPs in position 1 furthermore demonstrate high variability over time (∆β; for type I probes Supplementary Fig. S2b). f Example of a probe with 0-position SNP (SNP-II-0) showing a tri-modal  β value distribution. g Example of a probe with 1-position SNP (SNP-II-1) showing a tri-modal intensity distribution