Table 3 Summary of genes in differentially methylated probes (DMPs), differentially methylated regions (DMRs) and pathway enrichment analyses in correlational analyses performed in T0–T1, as well as with covariates including clinical symptoms variations and response status. Statistically significant genes are highlighted in bold
Single CpG site analysis—Whole cohort | ||
|---|---|---|
Genes | Main known associations | |
Genes in DMPs related to inflammatory and immune processes | PVRL4 | Breast and ovarian cancer |
EPB41 | Liver and lung cancer | |
OTUB1 | Pro-carcinogenic roles | |
FAM20C | Bladder, brain and stomach cancer | |
Genes in DMPs related to psychiatric disorders | ADARB1 | Bipolar disorder, MDD, schizophrenia |
Single CpG site analysis—Female cohort | ||
|---|---|---|
Genes | Main known associations | |
Genes in DMPs related to inflammatory and immune processes | FOXK1 | Some types of cancer |
CYB5B | Some types of cancer | |
PHLPP2 | Some types of cancer | |
FAM20C | Bladder, brain and stomach cancer | |
Genes in DMPs related to psychiatric disorders | EIF3H | Autism spectrum |
DOCK4 | Schizophrenia and autism | |
Regional analysis—Whole cohort | ||
|---|---|---|
Genes | Main known associations | |
Genes in DMRs related to inflammatory and immune processes | MCF2L | Inflammatory processes and osteoarthritis |
RUNX3 | Oncogenic and tumor suppression functions | |
MIR637 | Renal cell carcinoma | |
FOXK2 | Various cancer cell types | |
POU6F1 | Lung cancer | |
CCRL2 | Lung cancer | |
NLRP6 | Inflammatory processes | |
GALNT2 | Various cancer cell types | |
Genes in DMRs related to psychiatric disorders | SLC25A24 | Conduct disorder |
Genes in DMRs related to neuroplasticity | POU6F1 | Neurogenesis and neuroplasticity |
Regional analysis—Female cohort | ||
|---|---|---|
Genes | Main known associations | |
Genes in DMRs related to inflammatory and immune processes | LAT | Immune processes |
FAM30A | Gallbladder cancer | |
DLX4 | Various cancer cell types | |
RUNX3 | Oncogenic and tumor suppression functions | |
MCF2L | Inflammatory processes and osteoarthritis | |
FOXK2 | Various cancer cell types | |
MIR637 | Renal cell carcinoma | |
AVPI1 | Melanoma | |
Genes in DMRs related to psychiatric disorders | ZFP57 | Autism spectrum and PTSD symptoms |
POLD4 | Schizophrenia | |
RIPOR2 | Altered in trauma exposure | |
TRIM10 | Schizophrenia | |
GAS7 | Schizophrenia | |
ADORA2A | Anxiety disorders | |
AVPI1 | Alcohol dependence | |
DAZL | Schizophrenia | |
FAM124B | Anorexia nervosa | |
Genes in DMRs related to neuroplasticity | DLX4 | Neurogenesis and Alzheimer disease |
POU6F1 | Neurogenesis and neuroplasticity | |
Gene set and biological pathway analysis—Female cohort | |
|---|---|
Main pathways | |
Gene ontology biological processes | Oxidative stress |
Gene ontology molecular functions | Regulation of transcriptional activity |
Growth factor activity | |
Glutamate receptor binding and other binding functions | |
Gene ontology cellular components | Neuron projection membrane and axolemma terms |
KEGG pathways | Alcoholism pathway |
Reactome pathways | DNA maintenance |
MSigDB | MYC targets V2 |
Transcription factor targets | Targets of IRF7, IRF2, AUTS2 |