Fig. 1

Epigenome-wide association study of IAP and NIAP infants demonstrates differentially methylated regions enriched with immune response genes. A Volcano plot of differentially methylated regions significantly associated with IAP status. X-axis represents the average methylation change from NIAP group (delta methylation ratio), and the y-axis shows the log region size in base pairs. Points are colored according to maximum observed methylation difference in region. N = 30 B Circular visualization of significant SNP-CpG association pairs showing chromosomal location of associated markers. C Dot chart of summary statistics from gene ontology enrichment analysis of the infection-prone associated methylation signature highlighting significantly enriched pathways. The y-axis shows gene set nomenclature, point size reflects total count of differentially methylated genes, points are ranked by the percentage of genes in the set covered, and colored according to false discovery rate adjusted P-value. Diff Differentially, DMRs differentially methylated regions, IAP infection allergy/asthma prone, max maximum, bp base pairs, P.DE p-value for over-representation of the GO or KEGG term, Coverage percentage of genes identified within specified pathway