Fig. 6

Identification of SASEs and prediction of their target genes in mice with ARHL. A, B Western blot analyses of H3K9ac, H3K18ac, and H3K27ac in the cochleae of 6 W and12 M mice. The statistical significance was represented as * p < 0.05; **p < 0.01; ***p < 0.001;****p < 0.0001. Bar graph results are means ± SD from 6 independent experiments. C The distribution of SASEs region peaks around the transcription start sites and average ATAC-seq signal density in the young state and aging state of cochlea surrounding the SASE regions. D Geneplots of identified SASEs. The position of different peaks was labeled with green cubes and peak numbers. E Geneplots of SASE-linked genes. The position of different peaks and gene exons was marked with green cubes. The thick green line represents the location of SASE