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Fig. 5 | Clinical Epigenetics

Fig. 5

From: The chromatin accessibility and transcriptomic landscape of the aging mice cochlea and the identification of potential functional super-enhancers in age-related hearing loss

Fig. 5

Integrated analysis of chromatin accessibility and gene expression during ARHL development. A Venn diagram showing the number of genes in different ATAC and mRNA state, providing a more reliable analysis of the regulatory mechanisms underlying age-related changes in gene expression. B GO enrichment analysis of differentially expressed genes with different peaks. C KEGG analysis of differentially expressed genes with different peaks. D Gene element-based correlation analyses between peak intensity and gene expression, suggesting the importance of chromatin accessibility in the promoter and 5’UTR regions for proximal regulation. R is Pearson’s correlation coefficient and P is the significance test for the correlation coefficient. E The number of genes containing different numbers of peaks in the promoter regions in two groups. Most genes in both groups have 1–3 peaks in their promoter regions. F Comparing expression distribution of up or downregulated genes based on whether they contain promoter peaks or not

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Clinical Epigenetics

ISSN: 1868-7083

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