Fig. 2

Genome-wide accessible chromatin profiling of cochleae of ARHL and normal mice. A Enrichment peaks around the transcription start sites (TSSs), and comparison of the average sequencing depth in TSS of two groups. (X: the distance from the site to the TSS, Y: the average sequencing depth of the site). B Genome-wide chromatin accessibility of control and aging cochlea. C Volcano plot of differential analysis to the peaks during the aging process of cochlea, which consist of 34,269 increased and 59,511 decreased peaks. D The distribution plot of the fragments length revealed that the fragments detected in aging cochleae were shorter overall than in control cochleae. E Genomic annotation of identified different ATAC-seq peaks. F The enrichment heatmap of nucleosome binding sites revealed a looser or more relaxed chromatin structure in the control cochleae. G The geneplot of Hmgb1 in different bioreplicated samples (the arrow indicates the transcription start site and direction, the green region represents the exonic region, and the higher the peak, the stronger the accessibility of that region)