Fig. 5
The role of HDACs in developing, protecting, and inhibiting pancreatic β-cells. The regulatory contribution to pathways such as cell cycle, glucose and KCL stimulation, SIRT1-PGC1-Pparɣ pathway, transcriptional regulation in coordination with GLUT transporter, and zinc transport (Slc39a5) inhibition are shown. Dark green denotes activation, black arrows denote regulation, and red arrows with blunt ends denote negative regulation