Clinical Epigenetics

Table 3 Multivariable models using maternal characteristics to predict gestational age, epigenetic gestational age, acceleration of gestational age in CHILD and START

From: Consistent cord blood DNA methylation signatures of gestational age between South Asian and white European cohorts

		CHILD
		GA			DNAm GA			GAA
		Estimate	Error	P-value	Estimate	Error	P-value	Estimate	Error	P-value
	Intercept	39.73	0.54	2.14E− 209	41.33	0.34	5.10E-281	0.21	0.26	0.43
Predictors	Age (mother)							0.01	0.01	0.068
	Parity	− 0.14	0.07	0.061	-0.14	0.04	0.0015	-0.11	0.03	0.0011
	BMI	− 0.10	0.04	0.017	-0.04	0.02	0.085
	Weight	0.04	0.01	0.0051	0.015	0.01	0.071
	Weight gain	0.05	0.01	1.04E04	0.023	0.01	0.0025
	Diabetes mellitus	− 1.01	0.33	0.0023	-0.66	0.19	7.39E-04	-0.27	0.14	0.055
	Pre-eclamp	− 0.62	0.37	0.096
	Smoking
	Smoke
	Disadvantage
	Conscious diet
	Western diet
	Plant-based diet
	Newborn sex				-0.15	0.08	0.058	-0.17	0.06	0.0023
Model Metric	P-value	6.19E− 06			2.77E− 06			1.71E− 04
	squared	8.03%			8.52%			5.29%

		START
		GA			DNAm GA			GAA
		Estimate	Error	P-value	Estimate	Error	P-value	Estimate	Error	P-value
	Intercept	41.91	0.64	1.04E− 243	41.90	0.44	3.72E−317	0.25	0.10	0.012
Predictors	Age (mother)	− 0.04	0.01	3.1E04	-0.01	0.01	0.13
	Parity				-0.11	0.04	0.0095	-0.09	0.03	0.0033
	BMI
	Weight
	Weight gain							−0.01	0.00	0.034
	Diabetes mellitus	− 0.34	0.10	8.76E−04	-0.16	0.07	0.019
	Pre-eclamp	− 0.76	0.53	0.15	-0.58	0.35	0.10
	Smoking							0.38	0.24	0.11
	Smoke
	Disadvantage
	Conscious diet	− 0.14	0.06	0.028
	Western diet	0.16	0.07	0.034				-0.08	0.04	0.033
	Plant-based diet
	Newborn sex				-0.11	0.07	0.11	-0.08	0.05	0.084
Model Metric	P-value	1.35E− 08			2.51E− 05			0.00056
	squared	7.90%			4.50%			3.40%

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