Fig. 6

Effects of HTG on histone lactylation. a Number of lactylated proteins enriched in genetic information processing via KEGG pathway analysis. b Cluster of lactylated proteins involved in regulation of RNA splicing. c Cluster of lactylated proteins (top 20) involved in regulation of cellular metabolic process. d PPI analysis of H2BC13. e Histone lactylation. f Western blot analysis of H2B, H4 lactylation levels