Fig. 5

Cause-specific subhazard ratios for CVD and lung cancer-associated mortality. Each line corresponds to a separate model. Both models were adjusted for: age at entry, sex, BMI, years of education, and alcohol consumption. Presented hazard ratios correspond to the standardized signatures. Dashed lines represent cause-specific deaths at individual values of the epigenetic signature (so-called rug plot), whereby lines along the top of the figure correspond to CVD-related death, and along the bottom lung cancer-related death