Hypermethylation of tumor suppressor lncRNA MEF2C-AS1 frequently happened in patients at all stages of colorectal carcinogenesis

Table 1 Differential analysis of MEF2C-AS1 methylation among 12 CRC patients in in-house step 1

CpG site^a	Location	Methylation level			p value^c
CpG site^a	Location	Lesion tissue	Adjacent normal tissue	Difference^b
cg04694437	chr5: 88,185,051	0.63	0.47	0.16	5.54E − 04
cg08966485	chr5: 88,185,090	0.66	0.37	0.29	2.69E − 07
cg15297153	chr5: 88,185,314	0.67	0.03	0.64	3.31E − 04
cg10571951	chr5: 88,185,387	0.75	0.06	0.69	5.11E − 08
cg12621171	chr5: 88,185,768	0.45	0.04	0.41	3.32E − 09
cg18109838	chr5: 88,185,987	0.43	0.07	0.36	2.23E − 03
Mean		0.60	0.17	0.43	2.15E − 07

CRC, colorectal cancer
^aCpG site in the promoter region of MEF2C-AS1
^bMethylation difference was calculated between lesion tissue and adjacent normal tissue
^cPaired student’s t test

ISSN: 1868-7083