Fig. 1

Differential DNA methylation distribution in decidual tissues. A Circular plot of different genes in the decidual samples. The two innermost circles represent the differential hypermethylation and hypomethylation frequencies. B Manhattan plot showing P value of each gene’s methylation level in decidua between RSA and controls. The horizontal line is the suggestive DNA methylation sequence significance threshold cutoff. C Enrichment analysis of DMGs. D Volcano plot for the DEGs. E Heatmap plot of the top 40 DEGs (20 upregulated DEGs and 20 downregulated DEGs). F Enrichment analysis of DEGs