Fig. 5
Performance comparison between the conventional model, 3-marker methylation model, and integrated model. a, b ROC curve of the 3-marker methylation model and integrated model as compared the conventional model in the model development and validation cohorts, respectively. Comparison of AUC values was conducted by Hanley and McNeil tests. c, d The sensitivity, specificity, and accuracy of the 3-marker methylation model and integrated model as compared the conventional model in the model development and validation cohorts, respectively. e, f Distribution of predicted LNM status in EGC using 3-marker model, Integrated model and conventional model in the model development and validation cohorts, respectively. Statistical significance was assessed by χ2 test. *p < 0.05, **p < 0.01, ***p < 0.001, NS., not statistically significant