Fig. 2

Methylation assays in high-risk and low-risk patients. Adenomas were considered non-hypomethylated (in dark gray) when assays showed methylation levels above 60%. Adenomas were considered hypomethylated (in white) when assays displayed methylation level below 60%. a Global L1 methylation assay. b Intragenic L1-MET methylation assay. c Combination of the two methylation assays: we consider hypomethylated patients with at least one assay below 60%