Fig. 5
From: The dynamic broad epigenetic (H3K4me3, H3K27ac) domain as a mark of essential genes
Transcription factory containing enhancer, super-enhancer, and broad epigenetic domain interactome. The transcription factory, a phase-separated condensate, contains high concentrations of chromatin modifying enzymes (e.g., CBP/p300, PRMT1), chromatin remodelers, Mediator (and/or Insulator), topoisomerases, and cell-type specific transcription factors. The transcription factors contribute to the localization of the enhancer/super-enhancers and interaction with the genes with the broad epigenetic domain