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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Inhibition of HDAC4 by GSK3β leads to downregulation of KLF5 and ASK1 and prevents the progression of intravertebral disc degeneration

Fig. 5

GSK3β alleviates IDD by inhibiting HDAC4 expression. a Changes in the disc height index (DHI). b Apoptosis determined by TUNEL assay (200×). c GSK3β, HDAC4, Bcl-2, Bax, and cleaved caspase-3 protein expression determined by Western blotting. d Mechanical pain threshold. e Thermal sensitivity threshold; *p < 0.05 versus control; #p < 0.05 versus oe-NC + oe-NC; &p < 0.05 versus oe-GSK3β + oe-NC. n = 9 for animal experiments; cell experiments were performed in triplicate

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Clinical Epigenetics

ISSN: 1868-7083

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