Fig. 1
From: Histone methyltransferase SMYD2: ubiquitous regulator of disease
A schematic diagram of protein methylation on lysine residues. Protein lysine methyltransferases (PKMTs) catalyze monomethylation (Kme1), dimethylation (Kme2), and trimethylation (Kme3) of proteins on the ε-amine group of lysine by using S-adenosyl-l-methionine (AdoMet) as the primary methylgroup donor. This modification is reversible and can be erased by protein lysine demethylases (PKDMs)