Fig. 1

DMRs identified by Comb-p in WHI and validated in FHS at the a SLC9A1, b SLC1A5, and c TNRC6C loci. Negative logarithms of EWAS p values are shown as a function of the genomic coordinate. EWAS p values from WHI are in red and FHS in green. Dotted lines demarcate the DMR boundaries. Shapes for each point indicate the direction of association of the CpG site methylation with incident CVD