Fig. 1

The multi-step process of atherogenesis: Activation of the endothelium, monocyte activation and recruitment, leukocyte capture, rolling, adhesion, firm adhesion, macrophage differentiation, plaque development and stability. Apabetalone downregulates the transcription of each protein labeled in the illustration, thus impacting each step of atherogenesis. At the plaque, circulating and local cytokine expression from endothelial cells and monocytes are downregulated by apabetalone. Activation panel: pink speckles represent multiple cytokine secretion