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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Aberrant methylation of Pax3 gene and neural tube defects in association with exposure to polycyclic aromatic hydrocarbons

Fig. 2

PAX3 methylation pattern assayed by Sequenom EpiTYPER in NTD cases and controls. a Mean methylation level of PAX3 promoter region (amplicon 1 and amplicon 2) between NTD cases and controls. b Mean methylation level of PAX3 body region (amplicon 3) between NTD cases and controls. c–e Methylation levels for each CpG site between NTD cases and controls in promoter (c, d) and body region (e). TSS1500, TSS200, 5′URT, and the 1st exon were defined as the promoter region of PAX3 gene in this study. The significance of differences was calculated using Independent t-test. *P <  0.05, **P <  0.01, ***P <  0.001, compared with control group. #P <  0.05, compared with control group after FDR adjustment

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Clinical Epigenetics

ISSN: 1868-7083

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