Fig. 5

Proposed model for methylation-dependent TFAP2A binding and regulation of NRBP1 expression in gout. a In healthy subjects, TFAP2A binds to methylated B1, which suppresses the transcription of NRBP1. b In contrast, hypomethylation of B1 at the promoter region of NRBP1 abrogates TFAP2A binding, which results in elevated NRBP1 expression in gout