Skip to main content
Fig. 4 | Clinical Epigenetics

Fig. 4

From: DNA hypomethylation of a transcription factor binding site within the promoter of a gout risk gene NRBP1 upregulates its expression by inhibition of TFAP2A binding

Fig. 4

Hypomethylation of B1 is associated with increased NRBP1 expression in gout patients. a Bisulfite pyrosequencing showed DNA methylation on B1 at the promoter of NRBP1 is significantly lower in gout patients (n = 15) comparing to healthy controls (n = 17). Data are represented as mean ± SEM. (P value = 0.005, Student’s t test, unpaired, two-sided). b A significant negative association between NRBP1 gene expression and DNA methylation on B1 in the tested subjects (P value = 0.0113)

Back to article page

Clinical Epigenetics

ISSN: 1868-7083

Contact us