Fig. 2

Cord blood leptin levels correlations with DNA methylation. Cord blood leptin levels were correlated with DNA methylation at a PPARGC1α-CpG3, b PPARGC1α-CpG4, c PRDM16-CpG2, and d PRDM16-CpG4. Unstandardized residuals were first computed for cord blood leptin levels using linear regression and gestational age, newborn’s sex and weight as covariates and for DNA methylation levels using linear regression and gestational age, newborn’s sex and weight, smoking during pregnancy, weight gain between the first and second trimester and maternal BMI at the first trimester as covariates. The residuals were then used to compute Spearman’s correlation coefficients