Figure 1
From: Synthetic epigenetics—towards intelligent control of epigenetic states and cell identity
The concept of epigenetic editing. Targeting device, a sequence-specific DNA binding domain which can be redesigned to recognize desired sequences is fused to an effector domain, which can modify the epigenetic state of the targeted locus, leading to a persistent biological effect (gene activation or repression). Green lollipops represent introduced modification of either DNA bases or histone tails.